#FungalManipulation #PlantFungiInteraction #SymbioticFungi #PathogenicFungi #ProteinStructures #AMFungi #EffectorProteins #PlantHealth #Agriculture #AlphaFold2 #PlantMicrobeInteractions #GatsbyCharitableFoundation #SLCU
Ua ʻike ka poʻe ʻepekema ma ke Kulanui ʻo Sainsbury Laboratory Cambridge (SLCU) i kahi ʻike makaʻala, e hōʻike ana i ka symbiotic a me ka pathogenic fungi, ʻoiai he pili lōʻihi, hoʻohana i kahi hui like o nā protein e hoʻoponopono a noho i nā mea kanu. ʻO kēia noiʻi, ka mea i hoʻohālikelike i nā protein huna mai kēia mau haʻuki me ka hoʻohana ʻana i ka ʻenehana AI kiʻekiʻe, e hoʻomālamalama i nā hana i lalo o ka pilina o nā mea kanu-fungi. He hopena koʻikoʻi ka ʻike no ka mahiʻai a me nā kaiaola kūlohelohe, no ka mea, ʻo ka hoʻomaopopo ʻana i kēia mau mea hana molekala hiki ke hoʻonui i ka pilina o nā mea kanu-fungi e pono ai a ke kau nei hoʻi i nā pilikia o ka piʻi ʻana i nā pathogens.
Ua hoʻolaʻa ʻia ʻo Sebastian Schornack a me kāna hui noiʻi ma SLCU i ka ʻike ʻana a me ka hoʻohālikelike ʻana i nā hopena arbuscular mycorrhiza (AM) hou, ʻo ia nā protein i hūnā ʻia e nā fungi symbiotic e hoʻomaʻamaʻa i ko lākou noho ʻana i nā aʻa mea kanu. I kā lākou ʻimi ʻana e wehe i nā hoʻolālā i hoʻohana ʻia e nā fungi pathogenic a me symbiotic, ua hoʻohana ka hui i ka polokalamu kamepiula AlphaFold2 AI, kahi mea hana ikaika no ka wānana ʻana i nā kūkulu protein. ʻO kēia ka mea i hiki ai iā lākou ke hoʻohālikelike i nā protein huna o nā fungi symbiotic a me nā pathogenic, i ka hopena i ka loaʻa ʻana o kahi pūʻulu like ʻole o nā protein i hoʻopaʻa ʻia i loko o nā genomes o nā ʻano haʻani ʻelua.
Loaʻa i nā hopena o ka haʻawina i ke ola kino a me ka mahiʻai. ʻO nā fungi Symbiotic, e like me ka AM fungi, he hana koʻikoʻi i ka lawe ʻana i ka meaʻai, ka hoʻoulu ʻana o ka mea kanu, a me ka pale ʻana i nā pathogens. Ma ka ʻaoʻao ʻē aʻe, ʻo nā fungi pathogenic, e like me Fusarium oxysporum, he mau pathogens luku e hoʻoweliweli i nā mea kanu koʻikoʻi e like me ka maiʻa a me nā lāʻau ʻaila. ʻO ka ʻike ʻia ʻana o nā protein kaʻana like, ʻike ʻia ʻo Fusarium oxysporum lycopersici dual-domain proteins (FOLDs), e hōʻike ana e kōkua kēia mau protein i ka hiki o nā fungi symbiotic a me nā pathogenic e noho pono i nā mea kanu.
Hoʻomaopopo ʻo Kauka Schornack ʻoiai ʻo ka hoʻomaikaʻi ʻana i nā pilina AM i nā mea kanu hiki ke pōmaikaʻi i ka ulu ʻana o nā mea kanu, hiki nō ke hoʻonui i ko lākou nāwaliwali i nā pathogens. Ke hāpai nei kēia ʻike i nā nīnau e pili ana i ka noho ʻana a me ka hana ʻana o kēia mau protein i loko o nā fungi symbiotic a me nā hopena kūpono no ka pilina mea kanu-microbe.
He mea koʻikoʻi ka hoʻomaopopo ʻana i ka ʻokoʻa a me ka like o nā mea hopena i hoʻohana ʻia e nā symbionts a me nā pathogens no ka wehe ʻana i ka paʻakikī o ka pilina o nā mea kanu-microbe. ʻOiai ua aʻo maikaʻi ʻia nā protein effector i loko o ka pilina mea kanu-pathogen, ua kaupalena ʻia ko mākou ʻike o nā pilina mea kanu-symbiont, e like me nā mea e pili ana i nā haʻi AM. ʻO ka wehe ʻana i nā mea hana like ʻole e pili ana i ka pilina mea kanu-symbiont kahi mea nui o ka noiʻi ʻana a ka Schornack Team.
Ua hana ʻia kēia noiʻi ʻāina ma muli o ke kālā mai ka Gatsby Charitable Foundation, ka Royal Society, a me ka European Research Council.